Immunological and hematological effects of Irvingia gabonensis stem bark in sodium arsenite-exposed rats

This study investigated the effect of ethanol stem bark extract Irvingia gabonensis (ESEIG) on sodium arsenite (SA)-induced pro-inflammatory cytokines and hematological perturbations in Wistar rats. Fifty-five rats weighing 100 g - 179 were distributed into eleven groups (n=5). Group 1 had feed water only. 2 received 4.1 mg/kg body weight (kgbw) SA. Groups 3-11 SA and/or ESEIG. Treatment was done orally for 14 days. Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), interleukin-4 (IL-4) concentrations, hemoglobin (HB) concentration, red blood cell (RBC) count, packed volume (PCV), mean concentration (MCHC), (MCH), corpuscular (MCV), white (WBC) count its differentials platelet (PLT) used to investigate immunological effects Exposure produced significant (p ˂ 0.05) increases hepatic IL-1β, TNF-α, IL-10 IL-4 concentrations relative control. Administration also caused decreases HB, RBC, PCV, MCHC, MCH, MCV PLT WBC, lymphocytes, monocytes, eosinophils neutrophils compared with ESEIG concomitantly weeks after exposure, mitigated deleterious However, alone at various doses some assayed parameters, These results imply that may be protective against SA-induced inflammation derangements Its exclusive administration chronic basis slightly toxic.